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UniProt functional annotation for P20153 | ||
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| UniProt code: P20153. |
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| Organism: | |
Drosophila melanogaster (Fruit fly). |
| Taxonomy: | |
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. |
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| Function: | |
Receptor for ecdysone. May be an important modulator of insect metamorphosis. Plays an important part in embryonic and post- embryonic development. Binds to ecdysone response elements (ECRES) such as in the promoter region of s15 chorion gene. |
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| Subunit: | |
Heterodimer of USP and ECR. Only the heterodimer is capable of high-affinity binding to ecdysone. {ECO:0000269|PubMed:8247157}. |
| Subcellular location: | |
Nucleus. |
| Domain: | |
Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. |
| Similarity: | |
Belongs to the nuclear hormone receptor family. NR2 subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.