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PDBsum entry 2h4g

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Hydrolase PDB id
2h4g
Jmol
Contents
Protein chain
297 a.a.
Ligands
694
Waters ×98

References listed in PDB file
Key reference
Title Monocyclic thiophenes as protein tyrosine phosphatase 1b inhibitors: capturing interactions with asp48.
Authors Z.K.Wan, J.Lee, W.Xu, D.V.Erbe, D.Joseph-Mccarthy, B.C.Follows, Y.L.Zhang.
Ref. Bioorg.Med.Chem.Lett., 2006, 16, 4941-4945. [DOI no: 10.1016/j.bmcl.2006.06.051]
PubMed id 16806920
Abstract
A series of monocyclic thiophenes was designed and synthesized as PTP1B inhibitors. Guided by X-ray co-crystal structural information and computational modeling, rational design led to key interactions with Asp48 and improved inhibitory potency against PTP1B.
PROCHECK
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 Headers