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PDBsum entry 2h04
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References listed in PDB file
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Key reference
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Title
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Design and synthesis of potent, Non-Peptidic inhibitors of hptpbeta.
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Authors
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K.K.Amarasinghe,
A.G.Evdokimov,
A.G.Evidokimov,
K.Xu,
C.M.Clark,
M.B.Maier,
A.Srivastava,
A.O.Colson,
G.S.Gerwe,
G.E.Stake,
B.W.Howard,
M.E.Pokross,
J.L.Gray,
K.G.Peters.
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Ref.
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Bioorg Med Chem Lett, 2006,
16,
4252-4256.
[DOI no: ]
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PubMed id
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Abstract
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The sulfamic acid phosphotyrosine mimetic was coupled with a previously known
malonate template to obtain highly selective and potent inhibitors of HPTPbeta.
Potentially hydrolyzable malonate ester functionalities were replaced with
1,2,4-oxadiazoles without a significant effect on HPTPbeta potency.
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