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PDBsum entry 2h02
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Contents |
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* Residue conservation analysis
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PDB id:
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Hydrolase
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Title:
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Structural studies of protein tyrosine phosphatase beta catalytic domain in complex with inhibitors
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Structure:
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Protein tyrosine phosphatase, receptor type, b,. Chain: a, b. Fragment: catalytic domain, residues 1662-1973. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: ptprb. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Resolution:
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2.30Å
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R-factor:
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0.190
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R-free:
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0.244
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Authors:
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A.G.Evdokimov,M.E.Pokross,R.L.Walter,M.Mekel,J.L.Gray,K.G.Peters, M.B.Maier,K.D.Amarasinghe,C.M.Clark,R.Nichols
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Key ref:
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K.K.Amarasinghe
et al.
(2006).
Design and synthesis of potent, non-peptidic inhibitors of HPTPbeta.
Bioorg Med Chem Lett,
16,
4252-4256.
PubMed id:
DOI:
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Date:
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13-May-06
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Release date:
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13-Jun-06
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PROCHECK
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Headers
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References
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P23467
(PTPRB_HUMAN) -
Receptor-type tyrosine-protein phosphatase beta from Homo sapiens
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Seq:
Struc:
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1997 a.a.
278 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.3.1.3.48
- protein-tyrosine-phosphatase.
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Reaction:
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O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate
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O-phospho-L-tyrosyl-[protein]
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+
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H2O
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=
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L-tyrosyl-[protein]
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+
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phosphate
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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DOI no:
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Bioorg Med Chem Lett
16:4252-4256
(2006)
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PubMed id:
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Design and synthesis of potent, non-peptidic inhibitors of HPTPbeta.
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K.K.Amarasinghe,
A.G.Evdokimov,
A.G.Evidokimov,
K.Xu,
C.M.Clark,
M.B.Maier,
A.Srivastava,
A.O.Colson,
G.S.Gerwe,
G.E.Stake,
B.W.Howard,
M.E.Pokross,
J.L.Gray,
K.G.Peters.
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ABSTRACT
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The sulfamic acid phosphotyrosine mimetic was coupled with a previously known
malonate template to obtain highly selective and potent inhibitors of HPTPbeta.
Potentially hydrolyzable malonate ester functionalities were replaced with
1,2,4-oxadiazoles without a significant effect on HPTPbeta potency.
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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R.A.Neves Filho,
C.A.da Silva,
C.S.da Silva,
V.P.Brustein,
D.M.do Amaral Ferraz Navarro,
F.A.dos Santos,
L.C.Alves,
M.G.dos Santos Cavalcanti,
R.M.Srivastava,
and
M.das Graças Carneiro-Da-Cunha
(2009).
Improved microwave-mediated synthesis of 3-(3-Aryl-1,2,4-oxadiazol-5-yl)propionic acids and their larvicidal and fungal growth inhibitory properties.
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Chem Pharm Bull (Tokyo),
57,
819-825.
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R.Maccari,
R.Ottanà,
R.Ciurleo,
P.Paoli,
G.Manao,
G.Camici,
C.Laggner,
and
T.Langer
(2009).
Structure-based optimization of benzoic acids as inhibitors of protein tyrosine phosphatase 1B and low molecular weight protein tyrosine phosphatase.
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ChemMedChem,
4,
957-962.
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A.G.Evdokimov,
M.Pokross,
R.Walter,
M.Mekel,
B.Cox,
C.Li,
R.Bechard,
F.Genbauffe,
R.Andrews,
C.Diven,
B.Howard,
V.Rastogi,
J.Gray,
M.Maier,
and
K.G.Peters
(2006).
Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery.
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Acta Crystallogr D Biol Crystallogr,
62,
1435-1445.
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PDB codes:
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
codes are
shown on the right.
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Links
