UniProt functional annotation for Q9UII6

UniProt code: Q9UII6.

Organism: Homo sapiens (Human).
Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
 
Function: Dual specificity phosphatase that dephosphorylates MAPK8/JNK and MAPK14/p38, but not MAPK1/ERK2, in vitro. Exhibits intrinsic phosphatase activity towards both phospho-seryl/threonyl and -tyrosyl residues, with similar specific activities in vitro.
 
Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
Tissue specificity: Most abundantly expressed in the testis. Also found in the skeletal muscle. Testis-specific (at protein level).
Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Similarity: Contains 1 tyrosine-protein phosphatase domain.

Annotations taken from UniProtKB at the EBI.