PDBsum entry 2gp0

Hydrolase

PDB id: 2gp0

Contents

Protein chain

288 a.a. *

Ligands

PO4

GOL

Waters ×297

* Residue conservation analysis

PDB id:

2gp0

Name:

Hydrolase

Title:

Heptp catalytic domain (residues 44-339), s225d mutant

Structure:

Tyrosine-protein phosphatase non-receptor type 7. Chain: a. Fragment: catalytic domain (residues 65-360). Synonym: protein-tyrosine phosphatase lc-ptp, hematopoietic protein- tyrosine phosphatase, heptp. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ptpn7. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.05Å R-factor: 0.179 R-free: 0.206

Authors:

R.Page

Key ref:

R.Page and t.mustelin Heptp catalytic domain (residues 44-339), S225d mutant. To be published, .

Date:

15-Apr-06 Release date: 09-May-06

Protein chain

P35236  (PTN7_HUMAN) -  Tyrosine-protein phosphatase non-receptor type 7 from Homo sapiens

Seq: 360 a.a.

Struc: 288 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.3.1.3.48 - protein-tyrosine-phosphatase.
• Reaction: O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate

O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate (Bound ligand (Het Group name = PO4) corresponds exactly)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site