UniProt functional annotation for O35867



	UniProt functional annotation for O35867

UniProt code: O35867.

Organism: Rattus norvegicus (Rat).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus.

Function: Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May be involved in neurite formation. Inhibits protein phosphatase 1-alpha activity. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction.

Subunit: Possibly exists as a homodimer, homotrimer or a homotetramer. Interacts with F-actin, protein phosphatase 1 (PP1), neurabin-2, TGN38 and p70-S6K. {ECO:0000269|PubMed:10504266, ECO:0000269|PubMed:10514494, ECO:0000269|PubMed:20305656}.

Subcellular location: Cytoplasm, cytoskeleton. Cell junction, synapse, synaptosome.

Tissue specificity: Brain, and widely expressed in neural tissue. Highly concentrated in synapses of developed neurons. In developing neurons, concentrated in the lamellipodia of the growth cone.

Domain: Interacts with p70-S6K via its PDZ domain.

Domain: The PP1 binding region is natively unstructured, upon PP1 binding, it acquires structure, blocks a substrate-binding site, and restricts PP1 phosphatase specificity to a subset of substrates.

Annotations taken from UniProtKB at the EBI.


Organism:		Rattus norvegicus (Rat).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus.



Function:		Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May be involved in neurite formation. Inhibits protein phosphatase 1-alpha activity. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction.


Subunit:		Possibly exists as a homodimer, homotrimer or a homotetramer. Interacts with F-actin, protein phosphatase 1 (PP1), neurabin-2, TGN38 and p70-S6K. {ECO:0000269\|PubMed:10504266, ECO:0000269\|PubMed:10514494, ECO:0000269\|PubMed:20305656}.
Subcellular location:		Cytoplasm, cytoskeleton. Cell junction, synapse, synaptosome.
Tissue specificity:		Brain, and widely expressed in neural tissue. Highly concentrated in synapses of developed neurons. In developing neurons, concentrated in the lamellipodia of the growth cone.
Domain:		Interacts with p70-S6K via its PDZ domain.
Domain:		The PP1 binding region is natively unstructured, upon PP1 binding, it acquires structure, blocks a substrate-binding site, and restricts PP1 phosphatase specificity to a subset of substrates.