PDBsum entry 2g9n

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protein Protein-protein interface(s) links
Hydrolase PDB id
Protein chains
216 a.a. *
Waters ×226
* Residue conservation analysis
PDB id:
Name: Hydrolase
Title: Structure of the dead domain of human eukaryotic initiation eif4a
Structure: Eukaryotic initiation factor 4a-i. Chain: a, b. Fragment: dead domain. Synonym: atp-dependent RNA helicase eif4a-1, eif4a-i, eif-4 engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: eif4a1, ddx2a, eif4a. Expressed in: escherichia coli. Expression_system_taxid: 562.
2.25Å     R-factor:   0.180     R-free:   0.257
Authors: M.Hogbom,D.Ogg,C.Arrowsmith,H.Berglund,R.Collins,A.Edwards,M S.Flodin,A.Flores,S.Graslund,B.M.Hallberg,M.Hammarstrom,T.K P.Nilsson-Ehle,P.Nordlund,T.Nyman,C.Persson,J.Sagemark,P.St M.Sundstrom,A.G.Thorsell,J.Uppenberg,S.Van Den Berg,J.Weige L.Holmberg-Schiavone,Structural Genomics Consortium (Sgc)
Key ref: P.Schütz et al. (2010). Comparative structural analysis of human DEAD-box RNA helicases. PLoS One, 5, 12791-12791. PubMed id: 20941364
07-Mar-06     Release date:   14-Mar-06    
Go to PROCHECK summary

Protein chains
Pfam   ArchSchema ?
P60842  (IF4A1_HUMAN) -  Eukaryotic initiation factor 4A-I
406 a.a.
216 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 14 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: E.C.  - Rna helicase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + H2O = ADP + phosphate
+ H(2)O
+ phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biochemical function     nucleic acid binding     3 terms  


PLoS One 5:12791-12791 (2010)
PubMed id: 20941364  
Comparative structural analysis of human DEAD-box RNA helicases.
P.Schütz, T.Karlberg, S.van den Berg, R.Collins, L.Lehtiö, M.Högbom, L.Holmberg-Schiavone, W.Tempel, H.W.Park, M.Hammarström, M.Moche, A.G.Thorsell, H.Schüler.
No abstract given.


Literature references that cite this PDB file's key reference

  PubMed id Reference
22940866 A.L.Mallam, M.Del Campo, B.Gilman, D.J.Sidote, and A.M.Lambowitz (2012).
Structural basis for RNA-duplex recognition and unwinding by the DEAD-box helicase Mss116p.
  Nature, 490, 121-125.
PDB codes: 4db2 4db4
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