UniProt functional annotation for Q9ESK4



	UniProt functional annotation for Q9ESK4

UniProt code: Q9ESK4.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Seems to be involved in p53/TP53 activation and p53/TP53- dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs) (By similarity). {ECO:0000250}.

Subunit: Interacts with H3K4me3 and to a lesser extent with H3K4me2. Component of a mSin3A-like complex at least consisting of SIN3A, HDAC1, HDAC2, RBBP4/RbAp48, RBBP7/RbAp46, SAP30 and ING2. {ECO:0000250}.

Subcellular location: Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic. Localized to chromatin and nuclear matrix. Upon reduced PtdIns(5)P levels seems to be released from chromatin and, at least partially, translocated to the cytoplasm (By similarity). {ECO:0000250}.

Domain: The PHD-type zinc finger mediates the binding to H3K4me3. {ECO:0000250}.

Domain: The polybasic region (PBR) is responsive to the binding to phosphoinositides (PtdInsPs), including phosphatidylinositol 5- phosphate (PtdIns(5)P). {ECO:0000250}.

Ptm: Sumoylation enhances its association with SIN3A and is required for binding to some target gene promoters, this is the case for TMEM71. {ECO:0000250}.

Similarity: Belongs to the ING family. {ECO:0000305}.

Sequence caution: Sequence=AAH50003.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Seems to be involved in p53/TP53 activation and p53/TP53- dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs) (By similarity). {ECO:0000250}.


Subunit:		Interacts with H3K4me3 and to a lesser extent with H3K4me2. Component of a mSin3A-like complex at least consisting of SIN3A, HDAC1, HDAC2, RBBP4/RbAp48, RBBP7/RbAp46, SAP30 and ING2. {ECO:0000250}.
Subcellular location:		Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic. Localized to chromatin and nuclear matrix. Upon reduced PtdIns(5)P levels seems to be released from chromatin and, at least partially, translocated to the cytoplasm (By similarity). {ECO:0000250}.
Domain:		The PHD-type zinc finger mediates the binding to H3K4me3. {ECO:0000250}.
Domain:		The polybasic region (PBR) is responsive to the binding to phosphoinositides (PtdInsPs), including phosphatidylinositol 5- phosphate (PtdIns(5)P). {ECO:0000250}.
Ptm:		Sumoylation enhances its association with SIN3A and is required for binding to some target gene promoters, this is the case for TMEM71. {ECO:0000250}.
Similarity:		Belongs to the ING family. {ECO:0000305}.
Sequence caution:		Sequence=AAH50003.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};