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PDBsum entry 2g44
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Hormone/growth factor receptor
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PDB id
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2g44
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Contents |
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* Residue conservation analysis
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PDB id:
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| Name: |
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Hormone/growth factor receptor
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Title:
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Human estrogen receptor alpha ligand-binding domain in complex with obcp-1m-g and a glucocorticoid receptor interacting protein 1 nr box ii peptide
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Structure:
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Estrogen receptor. Chain: a, b. Fragment: ligand binding domain. Synonym: er, estradiol receptor, er-alpha. Engineered: yes. Mutation: yes. Nuclear receptor coactivator 2. Chain: c, d. Fragment: grip peptide.
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: esr1, esr, nr3a1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Other_details: this sequence occurs naturally in homo sapiens (humans).
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Resolution:
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2.65Å
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R-factor:
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0.219
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R-free:
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0.256
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Authors:
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S.S.Rajan,R.W.Hsieh,S.K.Sharma,G.L.Greene
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Key ref:
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R.W.Hsieh
Discovery and characterization of novel estrogen receptor agonist ligands and development of biochips for nuclear receptor drug discovery.
Thesis,
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Date:
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21-Feb-06
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Release date:
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09-Jan-07
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PROCHECK
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Headers
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References
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P03372
(ESR1_HUMAN) -
Estrogen receptor from Homo sapiens
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Seq:
Struc:
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595 a.a.
237 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 4 residue positions (black
crosses)
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Links
