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UniProt functional annotation for P55010 | ||
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| UniProt code: P55010. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]). |
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| Subunit: | |
Interacts with FMR1 isoform 6; this interaction occurs in a RNA-dependent manner. {ECO:0000269|PubMed:24658146}. |
| Similarity: | |
Belongs to the eIF-2-beta/eIF-5 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.