UniProt functional annotation for P00915

UniProt code: P00915.

Organism: Homo sapiens (Human).
Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
 
Function: Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea.
 
Catalytic activity: H(2)CO(3) = CO(2) + H(2)O.
Cofactor: Zinc.
Enzyme regulation: Activated by histamine, imidazole, L- adrenaline, L- and D-histidine, and L- and D-phenylalanine. Inhibited by coumarins, sulfonamide derivatives such as acetazolamide, benzenesulfonamide and derivatives (4- carboxyethylbenzene-sulfonamide, 4-carboxyethylbenzene-sulfonamide ethyl ester, 4-(acetyl-2-aminoethyl)benzene-sulfonamide, 4- aminoethylbenzene-sulfonamide), and 'prong inhibitors' BR15, BR17, BR22 and BR30. Activated by a short exposition to Foscarnet (phosphonoformate trisodium salt), but inhibited by a long one. Esterase activity weakly reduced by cyanamide.
Biophysicochemical properties: Kinetic parameters: KM=4.0 mM for CO(2); KM=15 mM for 4-nitrophenyl acetate;
Subcellular location: Cytoplasm.
Similarity: Belongs to the alpha-carbonic anhydrase family.

Annotations taken from UniProtKB at the EBI.