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PDBsum entry 2fw4

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Lyase PDB id
2fw4
Jmol
Contents
Protein chains
257 a.a.
Ligands
HIS ×2
Metals
_ZN ×2
Waters ×370

References listed in PDB file
Key reference
Title Carbonic anhydrase activators: the first X-Ray crystallographic study of an adduct of isoform i.
Authors C.Temperini, A.Scozzafava, C.T.Supuran.
Ref. Bioorg Med Chem Lett, 2006, 16, 5152-5156. [DOI no: 10.1016/j.bmcl.2006.07.021]
PubMed id 16870440
Abstract
The X-ray crystallographic structure for the adduct of an activator with human carbonic anhydrase isozyme I (hCA I) is reported. L-Histidine binds deep within the enzyme active site, participating in a network of hydrogen bonds involving its carboxylate moiety and the zinc-bound water molecule, as well as the imidazole of His200, being in van der Waals contacts with Thr199, His200, His64, and His67. This binding is very different from that to the other major cytosolic isozyme hCA II.
PROCHECK
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 Headers