UniProt functional annotation for Q92600



	UniProt functional annotation for Q92600

UniProt code: Q92600.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down- regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all. {ECO:0000250, ECO:0000269|PubMed:17189474, ECO:0000269|PubMed:18180299}.

Subunit: Homodimer. Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. Interacts with MYB, ATF2, RARA, RARB, RARG, RXRA, RXRB and RXRG. Identified in a complex with ATF2 bound to target DNA (By similarity). Interacts with NANOS2 (By similarity). Directly interacts with ZNF335. {ECO:0000250, ECO:0000269|PubMed:17189474, ECO:0000269|PubMed:18180299, ECO:0000269|PubMed:23232451}.

Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9JKY0}. Cytoplasm, P-body {ECO:0000250|UniProtKB:Q9JKY0}. Note=NANOS2 promotes its localization to P-body. {ECO:0000250|UniProtKB:Q9JKY0}.

Tissue specificity: Detected in spleen, thymus, prostate, testis, ovary and intestine. {ECO:0000269|PubMed:9447985}.

Similarity: Belongs to the CNOT9 family. {ECO:0000305}.

Sequence caution: Sequence=AAH07102.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down- regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all. {ECO:0000250, ECO:0000269\|PubMed:17189474, ECO:0000269\|PubMed:18180299}.


Subunit:		Homodimer. Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. Interacts with MYB, ATF2, RARA, RARB, RARG, RXRA, RXRB and RXRG. Identified in a complex with ATF2 bound to target DNA (By similarity). Interacts with NANOS2 (By similarity). Directly interacts with ZNF335. {ECO:0000250, ECO:0000269\|PubMed:17189474, ECO:0000269\|PubMed:18180299, ECO:0000269\|PubMed:23232451}.
Subcellular location:		Nucleus {ECO:0000250\|UniProtKB:Q9JKY0}. Cytoplasm, P-body {ECO:0000250\|UniProtKB:Q9JKY0}. Note=NANOS2 promotes its localization to P-body. {ECO:0000250\|UniProtKB:Q9JKY0}.
Tissue specificity:		Detected in spleen, thymus, prostate, testis, ovary and intestine. {ECO:0000269\|PubMed:9447985}.
Similarity:		Belongs to the CNOT9 family. {ECO:0000305}.
Sequence caution:		Sequence=AAH07102.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};