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Ligand clusters for UniProt code Q16539

Ligand clusters for Q16539: Mitogen-activated protein kinase 14 OS=Homo sapiens GN=MAPK14 PE=1 SV=3

Top 6 (of 19) ligand clusters
Cluster 1.
171 ligand types
208 ligands
Cluster 2.
17 ligand types
108 ligands
Cluster 3.
4 ligand types
8 ligands
Cluster 4.
4 ligand types
12 ligands
Cluster 5.
3 ligand types
12 ligands
Cluster 6.
1 ligand type
1 ligand
Representative protein: 3itzA  
 

Structures

PDB   Schematic diagram
3itzA    
3gfeA    
1wbnA    
1w83A    
1w82A    
 more ...

 

 Cluster 1 contains 171 ligand types (of which only 20 are listed. Click for all)

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Ligand Description


 
1. Ligand: ACT × 2
acetic acid
Acetate ion
PDB codes: 2zaz(A), 3kq7(A).


 
2. Ligand: BAX × 2
sorafenib
4-{4-[({[4-Chloro-3-(Trifluoromethyl) phenyl]amino}carbonyl)amino]phenoxy}-N-Methylpyridine- 2-
Carboxamide
PDB codes: 3gcs(A), 3heg(A).


 
3. Ligand: 1N1 × 1
dasatinib
N-(2-Chloro-6-Methylphenyl)-2-({6-[4-(2-Hydroxyethyl) piperazin-1-Yl]-2-Methylpyrimidin-4-
Yl}amino)-1,3- Thiazole-5-Carboxamide
PDB code: 3lfa(A).


 
4. Ligand: DMS × 1
dimethyl sulfoxide
Dimethyl sulfoxide
PDB code: 1wbv(A).


 
5. Ligand: STI × 1
imatinib
4-(4-Methyl-Piperazin-1-Ylmethyl)-N-[4-Methyl-3-(4- Pyridin-3-Yl-Pyrimidin-2-Ylamino)-Phenyl]-
Benzamide
PDB code: 3hec(A).


 
6. Ligand: BOG × 1
B-Octylglucoside
PDB code: 2fst(X).


 
7. Ligand: GOL × 2
Glycerol
PDB codes: 1wbv(A), 2i0h(A).


 
8. Ligand: SB5 × 1
4-(Fluorophenyl)-1-Cyclopropylmethyl-5-(2-Amino-4- Pyrimidinyl)imidazole
PDB code: 1bmk(A).


 
9. Ligand: SB6 × 1
4-(4-Fluorophenyl)-1-Cycloropropylmethyl-5-(4- Pyridyl)-Imidazole
PDB code: 1bl6(A).


 
10. Ligand: 279 × 1
N-Ethyl-4-{[5-(Methoxycarbamoyl)-2- Methylphenyl]amino}-5-Methylpyrrolo[2,1-F][1,2, 4]triazine-6-
Carboxamide
PDB code: 2rg5(A).


 
11. Ligand: BI5 × 1
4-Phenoxy-N-(Pyridin-2-Ylmethyl)benzamide
PDB code: 1zyj(A).


 
12. Ligand: SB4 × 1
4-(4-Fluorophenyl)-1-(4-Piperidinyl)-5-(2-Amino-4- Pyrimidinyl)-Imidazole
PDB code: 1bl7(A).


 
13. Ligand: WBT × 1
3-Fluoro-5-Morpholin-4-Yl-N-[1-(2-Pyridin-4- Ylethyl)-1h-Indol-6-Yl]benzamide
PDB code: 1wbt(A).


 
14. Ligand: 287 × 1
4-{[5-(Methoxycarbamoyl)-2-Methylphenyl]amino}-5- Methyl-N-[(1s)-1-Phenylethyl]pyrrolo[2,1-
F][1,2, 4]triazine-6-Carboxamide
PDB code: 2rg6(A).


 
15. Ligand: 3IP × 1
3-(Benzyloxy)pyridin-2-Amine
PDB code: 1w7h(A).


 
16. Ligand: DQO × 1
1-(2,6-Dichlorophenyl)-5-(2,4-Difluorophenyl)-7- Piperazin-1-Yl-3,4-Dihydroquinazolin-2(1h)-One
PDB code: 1m7q(A).


 
17. Ligand: GK4 × 1
N-(Cyclopropylmethyl)-2'-Methyl-5'-(5-Methyl-1,3,4- Oxadiazol-2-Yl)biphenyl-4-Carboxamide
PDB code: 2zb1(A).


 
18. Ligand: LI3 × 1
3-Fluoro-N-1h-Indol-5-Yl-5-Morpholin-4- Ylbenzamide
PDB code: 1wbv(A).


 
19. Ligand: 6NP × 1
6((s)-3-Benzylpiperazin-1-Yl)-3-(Naphthalen-2-Yl)-4- (Pyridin-4-Yl)pyrazine
PDB code: 1yqj(A).


 
20. Ligand: FPH × 1
3-(4-Fluorophenyl)-2-Pyridin-4-Yl-1h-Pyrrolo[3,2- B]pyridin-1-Ol
PDB code: 1oz1(A).

 + more. Press for full list
 

 

 Cluster 2 contains 17 ligand types

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Ligand Description


 
1. Ligand: BOG × 7
B-Octylglucoside
PDB codes: 1zyj(A), 1zz2(A), 2fsl(X), 2fsm(X), 2fso(X), 2fst(X),


 
2. Ligand: GOL × 1
Glycerol
PDB code: 1wbv(A).


 
3. Ligand: 287 × 1
4-{[5-(Methoxycarbamoyl)-2-Methylphenyl]amino}-5- Methyl-N-[(1s)-1-Phenylethyl]pyrrolo[2,1-
F][1,2, 4]triazine-6-Carboxamide
PDB code: 2rg6(A).


 
4. Ligand: D13 × 1
4-[5-(3-Iodo-Phenyl)-2-(4-Methanesulfinyl-Phenyl)-1h- Imidazol-4-Yl]-Pyridine
PDB code: 1ian(A).


 
5. Ligand: BOG × 63
B-Octylglucoside
PDB codes: 2npq(A), 3gcp(A), 3gcq(A), 3gcs(A), 3gcu(A), 3gcv(A), 3hec(A), 3hub(A), 3huc(A), 3hv3(A), 3hv4(A), 3hv5(A), 3hv6(A), 3hv7(A), 3iw5(A), 3iw6(A), 3iw7(A), 3iw8(A), 3l8s(A), 3lfa(A), 3lfb(A), 3lfc(A), 3lfd(A), 3lfe(A), 3lff(A), 3mgy(A), 3mh0(A), 3mh1(A), 3mh2(A), 3mh3(A), 3mpa(A), 3o8p(A), 3o8t(A), 3o8u(A), 3obj(A), 3od6(X), 3ody(X), 3odz(X), 3oef(X), 3pg3(A), 3qud(A), 3que(A), 3uvp(A), 3uvq(A), 3uvr(A), 3zs5(A), 3zsg(A), 3zsh(A), 3zsi(A), 4geo(A), 4l8m(A).


 
6. Ligand: IRG × 11
N~4~-Cyclopropyl-2-Phenylquinazoline-4,7-Diamine
PDB codes: 4dli(A), 4eh2(A), 4eh3(A), 4eh4(A), 4eh5(A), 4eh6(A), 4eh7(A), 4eh8(A), 4eh9(A), 4ehv(A).


 
7. Ligand: I46 × 8
2-Fluoro-4-[4-(4-Fluorophenyl)-1h-Pyrazol-3- Yl]pyridine
PDB codes: 2yis(A), 2yiw(A), 3hl7(A), 3hll(A), 3hp2(A), 3hp5(A), 3k3i(A), 3k3j(A).


 
8. Ligand: GG5 × 7
4-[3-(4-Fluorophenyl)-1h-Pyrazol-4-Yl]pyridine
PDB codes: 3hvc(A), 4ewq(A), 4f9w(A), 4f9y(A), 4fa2(A).


 
9. Ligand: GOL × 1
Glycerol
PDB code: 3mpt(A).


 
10. Ligand: 0O8 × 1
(1,1-Dimethylpiperidin-1-Ium-4-Yl) octadecyl hydrogen phosphate
PDB code: 4e6c(A).


 
11. Ligand: 0O9 × 1
(2s)-2-Methoxy-3-(Octadecyloxy)propyl (1r,2r,3r,4s,6s)- 2,3,4-Trihydroxy-6-(2-
Methylpropoxy)cyclohexyl hydrogen (s)-Phosphate
PDB code: 4e6a(A).


 
12. Ligand: 0OA × 1
(1r,2s,3r,4s,6s)-6-(Cyclohexylmethoxy)-2,3,4- Trihydroxycyclohexyl (2r)-2-Methoxy-3-
(Octadecyloxy) propyl hydrogen (s)-Phosphate
PDB code: 4e8a(A).


 
13. Ligand: 0SJ × 1
(1r,5s)-3-(4-Chlorobenzoyl)-1,2,3,4,5,6-Hexahydro-8h-1, 5-Methanopyrido[1,2-A][1,5]diazocin-8-One
PDB code: 4ehv(A).


 
14. Ligand: 29B × 1
4-[4-(4-Fluorophenyl)-1h-Pyrazol-3-Yl]pyridine
PDB code: 3roc(A).


 
15. Ligand: 3NE × 1
4-(Trifluoromethyl)-3-[3-(Trifluoromethyl)phenyl]-1,7- Dihydro-6h-Pyrazolo[3,4-B]pyridin-6-One
PDB code: 3new(A).


 
16. Ligand: 6RG × 1
2-Phenyl-N~4~-(2-Phenylethyl)quinazoline-4,7-Diamine
PDB code: 4dlj(A).


 
17. Ligand: P41 × 1
6-[4-(2-Fluorophenyl)-1,3-Oxazol-5-Yl]-N-(1- Methylethyl)-1,3-Benzothiazol-2-Amine
PDB code: 3c5u(A).

 

 Cluster 3 contains 4 ligand types

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Ligand Description


 
1. Ligand: I46 × 3
2-Fluoro-4-[4-(4-Fluorophenyl)-1h-Pyrazol-3-Yl]pyridine
PDB codes: 3hp2(A), 3hp5(A), 3k3i(A).


 
2. Ligand: BOG × 2
B-Octylglucoside
PDB codes: 3hv4(A), 3hv5(A).


 
3. Ligand: GOL × 2
Glycerol
PDB codes: 3iph(A), 4f9w(A).


 
4. Ligand: MWL × 1
3-Phenyl-4-(Pyridin-4-Yl)-6-[4-(Pyrimidin-2-Yl) piperazin-1-Yl]pyridazine
PDB code: 4ewq(A).

 

 Cluster 4 contains 4 ligand types

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Ligand Description


 
1. Ligand: ACT × 1
acetic acid
Acetate ion
PDB code: 3kq7(A).


 
2. Ligand: GOL × 6
Glycerol
PDB codes: 1wbs(A), 2zaz(A), 2zb1(A), 3d7z(A), 3e92(A), 3mpt(A).


 
3. Ligand: MES × 4
2-(N-Morpholino)-Ethanesulfonic acid
PDB codes: 3gcu(A), 3huc(A), 3hv4(A), 3hv5(A).


 
4. Ligand: EDO × 1
1,2-Ethanediol
PDB code: 3zs5(A).

 

 Cluster 5 contains 3 ligand types

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Ligand Description


 
1. Ligand: GOL × 7
Glycerol
PDB codes: 1ove(A), 2i0h(A), 2zb0(A), 3d83(A), 3e92(A), 3e93(A), 3iph(A).


 
2. Ligand: SO4 × 4
Sulfate ion
PDB codes: 1m7q(A), 1ouk(A), 1r39(A), 1yqj(A).


 
3. Ligand: BME × 1
Beta-Mercaptoethanol
PDB code: 4f9y(A).

 

 Cluster 6 contains 1 ligand type

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Ligand Description


 
1. Ligand: PEG × 1
Di(hydroxyethyl)ether
PDB code: 4ewq(A).

 

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