UniProt functional annotation for P07800

UniProt code: P07800.

Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
Taxonomy: Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Salmonella.
 
Function: Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P). Acts on free CheY-P. {ECO:0000269|PubMed:14636076, ECO:0000269|PubMed:1902474, ECO:0000269|PubMed:8399392, ECO:0000269|PubMed:8816756, ECO:0000269|PubMed:9837737}.
 
Subunit: Homodimer. Interacts (via C-terminus) with phosphorylated CheY (CheY-P). {ECO:0000269|PubMed:14636076, ECO:0000269|PubMed:16674976, ECO:0000269|PubMed:18083806, ECO:0000269|PubMed:8399392, ECO:0000269|PubMed:8816756, ECO:0000269|PubMed:9837737}.
Subcellular location: Cytoplasm.
Disruption phenotype: Cells lacking this gene display a strong clockwise motor bias; in combination with a yhjH disruption and overexpression of ycgR, cells switch from clockwise to a counterclockwise bias. {ECO:0000269|PubMed:20346719}.
Similarity: Belongs to the CheZ family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.