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PDBsum entry 2flr
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Hydrolase/blood clotting
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PDB id
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2flr
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Contents |
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96 a.a.
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254 a.a.
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151 a.a.
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* Residue conservation analysis
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PDB id:
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Hydrolase/blood clotting
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Title:
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Novel 5-azaindole factor viia inhibitors
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Structure:
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Coagulation factor vii. Chain: l. Fragment: light chain, residues 61-212. Engineered: yes. Coagulation factor vii. Chain: h. Fragment: heavy chain, residues 213-466. Engineered: yes. Tissue factor.
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: f3.
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Resolution:
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2.35Å
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R-factor:
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0.223
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R-free:
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0.259
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Authors:
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J.R.Riggs,H.Hu,A.Kolesnikov,Z.Tong,E.M.Leahy,K.E.Wesson,W.D.Shrader, D.Vijaykumar,T.A.Wahl,P.A.Sprengeler,M.J.Green,C.Yu,B.A.Katz, W.B.Young
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Key ref:
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J.R.Riggs
et al.
(2006).
Novel 5-azaindole factor VIIa inhibitors.
Bioorg Med Chem Lett,
16,
3197-3200.
PubMed id:
DOI:
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Date:
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06-Jan-06
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Release date:
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23-Jan-07
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PROCHECK
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Headers
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References
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P08709
(FA7_HUMAN) -
Coagulation factor VII from Homo sapiens
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Seq:
Struc:
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466 a.a.
96 a.a.
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Enzyme class:
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Chains L, H:
E.C.3.4.21.21
- coagulation factor VIIa.
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Reaction:
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Hydrolyzes one Arg-|-Ile bond in factor X to form factor Xa.
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DOI no:
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Bioorg Med Chem Lett
16:3197-3200
(2006)
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PubMed id:
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Novel 5-azaindole factor VIIa inhibitors.
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J.R.Riggs,
H.Hu,
A.Kolesnikov,
E.M.Leahy,
K.E.Wesson,
W.D.Shrader,
D.Vijaykumar,
T.A.Wahl,
Z.Tong,
P.A.Sprengeler,
M.J.Green,
C.Yu,
B.A.Katz,
E.Sanford,
M.Nguyen,
R.Cabuslay,
W.B.Young.
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ABSTRACT
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The discovery and development of 5-azaindole factor VIIa inhibitors will be
described.
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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S.Zhang,
W.X.Zhang,
and
Z.Xi
(2010).
Efficient one-pot synthesis of N-containing heterocycles by multicomponent coupling of silicon-tethered diynes, nitriles, and isocyanides through intramolecular cyclization of iminoacyl-Zr intermediates.
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Chemistry,
16,
8419-8426.
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T.Shiraishi,
S.Kadono,
M.Haramura,
H.Kodama,
Y.Ono,
H.Iikura,
T.Esaki,
T.Koga,
K.Hattori,
Y.Watanabe,
A.Sakamoto,
K.Yoshihashi,
T.Kitazawa,
K.Esaki,
M.Ohta,
H.Sato,
and
T.Kozono
(2010).
Design and synthesis of peptidomimetic factor VIIa inhibitors.
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Chem Pharm Bull (Tokyo),
58,
38-44.
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PDB code:
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S.Zhang,
X.Sun,
W.X.Zhang,
and
Z.Xi
(2009).
One-pot multicomponent synthesis of azaindoles and pyrroles from one molecule of a silicon-tethered diyne and three or two molecules of organonitriles mediated by zirconocene.
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Chemistry,
15,
12608-12617.
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
code is
shown on the right.
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Links
