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UniProt functional annotation for O18973 | ||
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| UniProt code: O18973. |
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| Organism: | |
Bos taurus (Bovine). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos. |
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| Function: | |
Rab effector protein acting as linker between gamma-adaptin and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase. {ECO:0000269|PubMed:16462746, ECO:0000269|PubMed:9323142}. |
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| Subunit: | |
Heterodimer with RABEP1. The heterodimer binds RAB4A and RAB5A that have been activated by GTP-binding. Binds TSC2, GGA1, GGA2, GGA3, AP1G1 and AP1G2 (By similarity). Interacts with RAB21, and with 100- fold lower affinity also with RAB22 (By similarity). Interacts with ubiquitinated EGFR. Interacts with RGS14; the interaction is GTP- dependent (By similarity). {ECO:0000250}. |
| Subcellular location: | |
Cytoplasm {ECO:0000269|PubMed:9323142}. Early endosome {ECO:0000269|PubMed:9323142}. Recycling endosome {ECO:0000269|PubMed:9323142}. |
| Tissue specificity: | |
Detected in brain. {ECO:0000269|PubMed:9323142}. |
| Ptm: | |
Monoubiquitinated. |
Annotations taken from UniProtKB at the EBI.