UniProt functional annotation for P31994



	UniProt functional annotation for P31994

UniProt code: P31994.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.

Subunit: Interacts with INPP5D/SHIP1. Interacts with FGR. Interacts with LYN. {ECO:0000269|PubMed:8327512, ECO:0000269|PubMed:9232445}.

Subunit: (Microbial infection) Isoform IIB1 interacts with measles virus protein N. Protein N is released in the blood following lysis of measles infected cells. This interaction presumably block inflammatory immune response. {ECO:0000269|PubMed:15914856}.

Subcellular location: Cell membrane; Single-pass type I membrane protein.

Tissue specificity: Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells.

Domain: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.

Ptm: Phosphorylated by the SRC-type Tyr-kinases LYN and BLK. {ECO:0000269|PubMed:8756631}.

Polymorphism: FCGR2B polymorphisms can influence susceptibility or resistance to malaria [MIM:611162]. {ECO:0000269|PubMed:17435165, ECO:0000269|PubMed:20385827}.

Disease: Systemic lupus erythematosus (SLE) [MIM:152700]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. {ECO:0000269|PubMed:12115230, ECO:0000269|PubMed:20385827}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.

Sequence caution: Sequence=CAA35645.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.


Subunit:		Interacts with INPP5D/SHIP1. Interacts with FGR. Interacts with LYN. {ECO:0000269\|PubMed:8327512, ECO:0000269\|PubMed:9232445}.
Subunit:		(Microbial infection) Isoform IIB1 interacts with measles virus protein N. Protein N is released in the blood following lysis of measles infected cells. This interaction presumably block inflammatory immune response. {ECO:0000269\|PubMed:15914856}.
Subcellular location:		Cell membrane; Single-pass type I membrane protein.
Tissue specificity:		Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells.
Domain:		Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
Ptm:		Phosphorylated by the SRC-type Tyr-kinases LYN and BLK. {ECO:0000269\|PubMed:8756631}.
Polymorphism:		FCGR2B polymorphisms can influence susceptibility or resistance to malaria [MIM:611162]. {ECO:0000269\|PubMed:17435165, ECO:0000269\|PubMed:20385827}.
Disease:		Systemic lupus erythematosus (SLE) [MIM:152700]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. {ECO:0000269\|PubMed:12115230, ECO:0000269\|PubMed:20385827}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
Sequence caution:		Sequence=CAA35645.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};