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Ligand clusters for UniProt code P18031

Ligand clusters for P18031: Tyrosine-protein phosphatase non-receptor type 1 OS=Homo sapiens GN=PTPN1 PE=1 SV=1

Top 6 (of 19) ligand clusters
Cluster 1.
102 ligand types
147 ligands
Cluster 2.
4 ligand types
4 ligands
Cluster 3.
1 ligand type
3 ligands
Cluster 4.
2 ligand types
7 ligands
Cluster 5.
2 ligand types
5 ligands
Cluster 6.
2 ligand types
2 ligands
Representative protein: 1pa1A  
 

Structures

PDB   Schematic diagram
1pa1A    
2cniA    
1xboA    
1q1mA    
2vevA    
 more ...

 

 Cluster 1 contains 102 ligand types (of which only 20 are listed. Click for all)

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Ligand Description


 
1. Ligand: ACT × 2
acetic acid
Acetate ion
PDB codes: 1ecv(A),


 
2. Ligand: PTR × 2
O-Phosphotyrosine
PDB codes: 1pty(A),


 
3. Ligand: 1C2 × 1
3(s)-Methylcarbamoyl-7-Sulfoamino-3,4-Dihydro-1h- Isoquinoline-2-Carboxylic acid tert-Butyl ester
PDB code: 2f6t(A).


 
4. Ligand: ENT × 1
3(r)-Methylcarbamoyl-7-Sulfoamino-3,4-Dihydro-1h- Isoquinoline-2-Carboxylic acid tert-Butyl ester
PDB code: 2f6y(A).


 
5. Ligand: SK2 × 1
(3r)-Methylcarbamoyl-7-Sulfoamino-3,4-Dihydro-1h- Isoquinoline-2-Carboxylic acid benzyl ester
PDB code: 2f6v(A).


 
6. Ligand: BPM × 2
4-Phosphonooxy-Phenyl-Methyl-[4-Phosphonooxy]benzen
PDB codes: 1aax(A),


 
7. Ligand: UN7 × 1
3-[3-(3(s)-Methylcarbamoyl-7-Sulfoamino-3,4,-Dihydro- 1h-Isoquinolin-2-Yl)-3-Oxo-Propyl]-
Benzoic acid
PDB code: 2f71(A).


 
8. Ligand: DFM × 1
N-Acetyl-L-Phenylalanyl-4- [Difluoro(phosphono)methyl]-L- Phenylalaninamide
PDB code: 2cmc(A).


 
9. Ligand: 429 × 1
2-{4-[2-Acetylamino-3-(4-Carboxymethoxy-3-Hydroxy- Phenyl)-Propionylamino]-Butoxy}-6-Hydroxy-
Benzoic acid methyl ester
PDB code: 1qxk(A).


 
10. Ligand: IZD × 1
Isothiazolidinone analog
PDB code: 2cm7(A).


 
11. Ligand: UN5 × 1
{3(s)-Methylcarbamoyl-2-[3-(3-Sulfoamino-Phenyl)- Propionyl]-1,2,3,4-Tetrahydro-Isoquinolin-7-Yl}-
Sulfamic acid
PDB code: 2f6z(A).


 
12. Ligand: INZ × 1
2-{4-[(2s)-2-[({[(1s)-1-Carboxy-2- Phenylethyl]amino}carbonyl)amino]-3-Oxo-3-
(Pentylamino)propyl]phenoxy}malonic acid
PDB code: 1g7f(A).


 
13. Ligand: 941 × 1
2-(4-{2-Tert-Butoxycarbonylamino-2-[4-(3-Hydroxy-2- Methoxycarbonyl-Phenoxy)-Butylcarbamoyl]-
Ethyl}- Phenoxy)-Malonic acid
PDB code: 1pyn(A).


 
14. Ligand: 989 × 1
2-{[4-(2-Acetylamino-2-Pentylcarbamoyl-Ethyl)- Naphthalen-1-Yl]-Oxalyl-Amino}-Benzoic acid
PDB code: 1nl9(A).


 
15. Ligand: F20 × 1
N-Benzoyl-L-Phenylalanyl-4-[(5s)-1,1-Dioxido- 3-Oxoisothiazolidin-5-Yl]-L- Phenylalaninamide
PDB code: 2cma(A).


 
16. Ligand: INX × 1
2-(Carboxymethoxy)-5-[(2s)-2-({(2s)-2-[(3- Carboxypropanoyl)amino] -3-Phenylpropanoyl}amino)-3-
Oxo-3-(Pentylamino)propyl]benzoic acid
PDB code: 1g7g(A).


 
17. Ligand: UN6 × 1
(3-{[3-(3-Sulfoamino-Phenyl)-Propionylamino]-Methyl}- Phenyl)-Sulfamic acid
PDB code: 2f70(A).


 
18. Ligand: FG1 × 1
N-[4-(2-{2-[3-(2-Bromo-Acetylamino)-Propionylamino]-3- Hydroxy-Propionylamino}-Ethyl)-Phenyl]-
Oxalamic acid
PDB code: 1nwe(A).


 
19. Ligand: OTA × 1
2-(Oxalyl-Amino)-4,5,6,7-Tetrahydro-Thieno[2,3- C]pyridine-3-Carboxylic acid
PDB code: 1c88(A).


 
20. Ligand: DFJ × 1
N-({4-[Difluoro(phosphono)methyl]phenyl} acetyl)-L-Phenylalanyl-4-[Difluoro(phosphono) methyl]-L-
Phenylalaninamide
PDB code: 2cne(A).

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 Cluster 2 contains 4 ligand types

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Ligand Description


 
1. Ligand: TBH × 1
5-(2-{2-[(Tert-Butoxy-Hydroxy-Methyl)-Amino]-1- Hydroxy-3-Phenyl-Propylamino}-3-Hydroxy-3-
Pentylamino- Propyl)-2-Carboxymethoxy-Benzoic acid
PDB code: 1jf7(A).


 
2. Ligand: BB3 × 1
3-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6- Sulfonic acid dimethylamide
PDB code: 1t48(A).


 
3. Ligand: 892 × 1
3-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran- 6-Sulfonic acid (4-Sulfamoyl-Phenyl)-Amide
PDB code: 1t49(A).


 
4. Ligand: FRJ × 1
3-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran- 6-Sulfonic acid [4-(Thiazol-2-Ylsulfamoyl)-
Phenyl]- Amide
PDB code: 1t4j(A).

 

 Cluster 3 contains 1 ligand type

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Ligand Description


 
1. Ligand: BOG × 3
B-Octylglucoside
PDB codes: 2cmb(A), 2cmc(A), 2cne(A).

 

 Cluster 4 contains 2 ligand types

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Ligand Description


 
1. Ligand: MPD × 1
(4s)-2-Methyl-2,4-Pentanediol
PDB code: 2cm2(A).


 
2. Ligand: GOL × 6
Glycerol
PDB codes: 1sug(A), 2cng(A), 3i7z(A), 3i80(A), 3qkp(A), 3qkq(A).

 

 Cluster 5 contains 2 ligand types

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Ligand Description


 
1. Ligand: MPD × 1
(4s)-2-Methyl-2,4-Pentanediol
PDB code: 2cm2(A).


 
2. Ligand: GOL × 4
Glycerol
PDB codes: 1sug(A), 3i80(A), 3qkp(A), 3qkq(A).

 

 Cluster 6 contains 2 ligand types

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Ligand Description


 
1. Ligand: GOL × 1
Glycerol
PDB code: 3i7z(A).


 
2. Ligand: PO4 × 1
Phosphate ion
PDB code: 2bgd(A).

 

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