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PDBsum entry 2f6w

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Hydrolase PDB id
2f6w
Jmol
Contents
Protein chain
297 a.a.
Ligands
UN3
Metals
_MG
_CL ×5
Waters ×327

References listed in PDB file
Key reference
Title 1,2,3,4-Tetrahydroisoquinolinyl sulfamic acids as phosphatase ptp1b inhibitors.
Authors S.R.Klopfenstein, A.G.Evdokimov, A.O.Colson, N.T.Fairweather, J.J.Neuman, M.B.Maier, J.L.Gray, G.S.Gerwe, G.E.Stake, B.W.Howard, J.A.Farmer, M.E.Pokross, T.R.Downs, B.Kasibhatla, K.G.Peters.
Ref. Bioorg Med Chem Lett, 2006, 16, 1574-1578. [DOI no: 10.1016/j.bmcl.2005.12.051]
PubMed id 16386905
Abstract
High-throughput screening of the P&GP corporate repository against several protein tyrosine phosphatases identified the sulfamic acid moiety as potential phosphotyrosine mimetic. Incorporation of the sulfamic acid onto a 1,2,3,4-tetrahydroisoquinoline scaffold provided a promising starting point for PTP1B inhibitor design.
PROCHECK
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