PDBsum entry 2f0a

Signaling protein

PDB id: 2f0a

Contents

Protein chains

92 a.a. *

89 a.a. *

85 a.a. *

89 a.a. *

Ligands

SO4

Metals

_CO

Waters ×152

* Residue conservation analysis

PDB id:

2f0a

Name:

Signaling protein

Title:

Crystal structure of monomeric uncomplexed form of xenopus dishevelled pdz domain

Structure:

Segment polarity protein dishevelled homolog dvl-2. Chain: a, b, c, d. Fragment: dishevelled pdz domain. Synonym: dishevelled-2, dsh homolog 2, xdsh. Engineered: yes

Source:

Xenopus laevis. African clawed frog. Organism_taxid: 8355. Gene: dvl2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Biol. unit:

Tetramer (from PQS)

Resolution:

1.80Å R-factor: 0.216 R-free: 0.253

Authors:

N.Friedland,L.-W.Hung,B.Cheyette,R.T.Moon,T.N.Earnest

Key ref:

N.Friedland et al. Conformational flexibility in the pdz domain of dishevelled induced by target binding. To be published, .

Date:

12-Nov-05 Release date: 22-Nov-05

Protein chain

P51142  (DVL2_XENLA) -  Segment polarity protein dishevelled homolog DVL-2 from Xenopus laevis

Seq: 736 a.a.

Struc: 92 a.a.*

Protein chain

P51142  (DVL2_XENLA) -  Segment polarity protein dishevelled homolog DVL-2 from Xenopus laevis

Seq: 736 a.a.

Struc: 89 a.a.*

Protein chain

P51142  (DVL2_XENLA) -  Segment polarity protein dishevelled homolog DVL-2 from Xenopus laevis

Seq: 736 a.a.

Struc: 85 a.a.*

Protein chain

P51142  (DVL2_XENLA) -  Segment polarity protein dishevelled homolog DVL-2 from Xenopus laevis

Seq: 736 a.a.

Struc: 89 a.a.*

* PDB and UniProt seqs differ at 20 residue positions (black crosses)