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PDBsum entry 2exe
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Contents |
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* Residue conservation analysis
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PDB id:
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Transferase
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Title:
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Crystal structure of the phosphorylated clk3
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Structure:
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Dual specificity protein kinase clk3. Chain: a. Fragment: protein kinase domain. Synonym: cdc-like kinase 3. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: clk3. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
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Resolution:
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2.35Å
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R-factor:
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0.227
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R-free:
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0.260
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Authors:
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E.Papagrigoriou,P.Rellos,S.Das,A.Bullock,L.J.Ball,A.Turnbull, P.Savitsky,O.Fedorov,C.Johansson,E.Ugochukwu,F.Sobott,F.Von Delft, A.Edwards,M.Sundstrom,J.Weigelt,C.Arrowsmith,S.Knapp,Structural Genomics Consortium (Sgc)
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Key ref:
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E.Papagrigoriou
et al.
Crystal structure of the phosphorylated clk3.
To be published,
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Date:
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08-Nov-05
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Release date:
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15-Nov-05
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PROCHECK
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Headers
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References
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P49761
(CLK3_HUMAN) -
Dual specificity protein kinase CLK3 from Homo sapiens
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Seq:
Struc:
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638 a.a.
262 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.2.7.12.1
- dual-specificity kinase.
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Reaction:
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1.
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L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
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2.
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L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H+
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3.
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L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
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L-seryl-[protein]
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+
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ATP
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=
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O-phospho-L-seryl-[protein]
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+
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ADP
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+
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H(+)
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L-threonyl-[protein]
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+
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ATP
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=
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O-phospho-L-threonyl-[protein]
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+
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ADP
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+
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H(+)
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L-tyrosyl-[protein]
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+
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ATP
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=
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O-phospho-L-tyrosyl-[protein]
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+
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ADP
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
