PDBsum entry 2exc

Transferase

PDB id: 2exc

Contents

Protein chain

335 a.a. *

Ligands

JNK

Waters ×85

* Residue conservation analysis

PDB id:

2exc

Name:

Transferase

Title:

Inhibitor complex of jnk3

Structure:

Mitogen-activated protein kinase 10. Chain: x. Synonym: stress-activated protein kinase jnk3, c-jun n-terminal kinase 3, map kinase p49 3f12. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.75Å R-factor: 0.213 R-free: 0.314

Authors:

Y.Xue

Key ref:

B.-M.Swahn et al. Inhibitor complex of jnk3. To be published, .

Date:

08-Nov-05 Release date: 14-Nov-06

Protein chain

P53779  (MK10_HUMAN) -  Mitogen-activated protein kinase 10 from Homo sapiens

Seq: 464 a.a.

Struc: 335 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.11.24 - mitogen-activated protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site