PDBsum entry 2etm

Transferase

PDB id: 2etm

Contents

Protein chains

262 a.a. *

Ligands

7PY ×2

Waters ×119

* Residue conservation analysis

PDB id:

2etm

Name:

Transferase

Title:

Crystal structure of focal adhesion kinase domain complexed with 7h- pyrrolo [2,3-d] pyrimidine derivative

Structure:

Focal adhesion kinase 1. Chain: a, b. Fragment: kinase domain. Synonym: fadk 1, pp125fak, protein- tyrosine kinase 2. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2, fak, fak1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Resolution:

2.30Å R-factor: 0.211 R-free: 0.295

Authors:

C.C.Lee

Key ref:

C.B.Andersen et al. Crystal structure of focal adhesion kinase domain complexed with ATP and novel 7h-Pyrrolo [2,3-D] pyrimidine scaffolds. To be published, .

Date:

27-Oct-05 Release date: 10-Oct-06

Protein chains

Q05397  (FAK1_HUMAN) -  Focal adhesion kinase 1 from Homo sapiens

Seq: 1052 a.a.

Struc: 262 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] (Bound ligand (Het Group name = 7PY) matches with 41.03% similarity) + ADP + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site