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UniProt functional annotation for Q9WUD2 | ||
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| UniProt code: Q9WUD2. |
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| Organism: | |
Rattus norvegicus (Rat). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. |
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| Function: | |
Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by growth factors, like IGF1, PDGF and morphogenetic neuropeptide/head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH (By similarity). {ECO:0000250, ECO:0000269|PubMed:10201375, ECO:0000269|PubMed:15249591}. |
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| Subunit: | |
Homotetramer (Probable). Interacts with a cAMP-dependent protein kinase type II regulatory subunit (PRKAR2A or PRKAR2B) and ACBD3. Interacts with SLC50A1; the interaction probably occurs intracellularly and depends on TRPV2 N-glycosylation. {ECO:0000269|PubMed:14991772, ECO:0000269|PubMed:15249591, ECO:0000305}. |
| Subcellular location: | |
Cell membrane; Multi-pass membrane protein. Cytoplasm {ECO:0000250}. Melanosome {ECO:0000250}. Note=Translocates from the cytoplasm to the plasma membrane upon ligand stimulation. {ECO:0000250}. |
| Tissue specificity: | |
Ubiquitously expressed. Expressed in dorsal root ganglia, trigeminal ganglia, spinal chord (Lissauer's tract, dorsal horn and dorsal columns) (at protein level). {ECO:0000269|PubMed:10201375, ECO:0000269|PubMed:15249591}. |
| Ptm: | |
N-glycosylated. {ECO:0000269|PubMed:14622291}. |
| Ptm: | |
Phosphorylated by PKA. {ECO:0000269|PubMed:15249591}. |
| Similarity: | |
Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV2 sub-subfamily. {ECO:0000305}. |
| Sequence caution: | |
Sequence=BAA93435.1; Type=Frameshift; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.