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UniProt functional annotation for Q80Y84 | ||
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| UniProt code: Q80Y84. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2. {ECO:0000269|PubMed:17310255, ECO:0000269|PubMed:17320160, ECO:0000269|PubMed:21960634}. |
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| Catalytic activity: | |
Reaction=3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)- [histone H3] + 3 O2 = 3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate; Xref=Rhea:RHEA:60208, Rhea:RHEA-COMP:15537, Rhea:RHEA-COMP:15547, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:29969, ChEBI:CHEBI:30031, ChEBI:CHEBI:61961; EC=1.14.11.67; Evidence={ECO:0000269|PubMed:17310255}; |
| Cofactor: | |
Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence={ECO:0000250}; Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000250}; |
| Subunit: | |
Interacts with FOXG1B, PAX9, MYC, MYCN and RB1. Interacts with HDAC1, HDAC4, HDAC5 and HDAC7. Interacts (via PHD-type 1 zinc finger) with histone H3 unmodified at 'Lys-4'; the interaction is inhibited when histone H3 is methylated at 'Arg-2' or 'Lys-4' (By similarity). {ECO:0000250|UniProtKB:Q9UGL1}. |
| Subcellular location: | |
Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355, ECO:0000255|PROSITE-ProRule:PRU00537, ECO:0000269|PubMed:14579128}. |
| Tissue specificity: | |
Present at highest levels in testis, where it is enriched in spermatogonia and pachytene cells (at protein level). {ECO:0000269|PubMed:12237901, ECO:0000269|PubMed:14516692, ECO:0000269|PubMed:14579128}. |
| Developmental stage: | |
Expressed in developing brain, mammary bud, thymus, teeth, whisker follicle, intervertebral disks, olfactory epithelium, eye, stomach and limbs. {ECO:0000269|PubMed:14516692}. |
| Domain: | |
Both the JmjC domain and the JmjN domain are required for enzymatic activity. However ARID and PHD-type 1 domain are not required for activity per se but contributed to recognition of the H3(1-21)K4me2 substrate peptide. {ECO:0000250|UniProtKB:Q9UGL1}. |
| Domain: | |
The 2 first PHD-type zinc finger domains are required for transcription repression activity. {ECO:0000250}. |
| Disruption phenotype: | |
Homozygous KDM5B-null mice are subviable, exhibit vertebral patterning defects, and manifest numerous behavioral abnormalities including increased anxiety, less sociability, and reduced long-term memory compared with that of wild-types. Heterozygous mice appear normal. {ECO:0000269|PubMed:30409806}. |
| Similarity: | |
Belongs to the JARID1 histone demethylase family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=BAD90482.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.