|
|
||
|
|
|
|
|
UniProt functional annotation for Q9NZL3 | ||
|
|
|
|
|
|
||
| UniProt code: Q9NZL3. |
|
||
| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
|
||
|
||
| Function: | |
May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells. {ECO:0000269|PubMed:20587513}. |
|
||
| Subunit: | |
Interacts with WT1. Interacts with DEPDC1A. {ECO:0000269|PubMed:12239212, ECO:0000269|PubMed:20587513}. |
| Subcellular location: | |
Nucleus {ECO:0000269|PubMed:12239212, ECO:0000269|PubMed:20587513, ECO:0000269|PubMed:23665872}. Note=Colocalizes with DEPDC1A at the nucleus. |
| Tissue specificity: | |
Ubiquitous. Mainly expressed in fetal tissues. {ECO:0000269|PubMed:12239212}. |
| Similarity: | |
Belongs to the krueppel C2H2-type zinc-finger protein family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.