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PDBsum entry 2eob
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Contents |
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* Residue conservation analysis
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PDB id:
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Hydrolase
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Title:
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Solution structure of the second sh2 domain from rat plc gamma-2
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Structure:
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1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2. Chain: a. Fragment: sh2 domain. Synonym: phosphoinositide phospholipasE C, plc-gamma-2, phospholipasE C-gamma-2, plc-iv. Engineered: yes
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Source:
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Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: plcg2. Other_details: cell-free protein synthesis
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NMR struc:
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20 models
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Authors:
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R.Sano,F.Hayashi,T.Nagashima,M.Yoshida,S.Yokoyama,Riken Structural Genomics/proteomics Initiative (Rsgi)
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Key ref:
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R.Sano
et al.
Solution structure of the second sh2 domain from rat plc gamma-2.
To be published,
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Date:
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29-Mar-07
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Release date:
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01-Apr-08
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PROCHECK
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Headers
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References
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P24135
(PLCG2_RAT) -
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 from Rattus norvegicus
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Seq:
Struc:
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1265 a.a.
124 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 13 residue positions (black
crosses)
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Enzyme class:
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E.C.3.1.4.11
- phosphoinositide phospholipase C.
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Pathway:
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myo-Inositol Phosphate Metabolism
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Reaction:
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a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H+
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1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)
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+
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H2O
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=
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1D-myo-inositol 1,4,5-trisphosphate
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+
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1,2-diacyl-sn-glycerol
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
