 |
PDBsum entry 2enq
|
|
|
|
|
 |
Contents |
 |
|
|
|
|
|
|
|
|
* Residue conservation analysis
|
|
|
|
|
|
PDB id:
|
|
|
|
| Name: |
|
Transferase
|
|
|
Title:
|
|
Solution structure of the c2 domain from human pi3-kinase p110 subunit alpha
|
|
Structure:
|
|
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform. Chain: a. Fragment: c2 domain. Synonym: pi3-kinase p110 subunit alpha, ptdins-3- kinase p110, pi3k. Engineered: yes
|
|
Source:
|
|
Homo sapiens. Human. Organism_taxid: 9606. Gene: pik3ca. Other_details: cell free protein synthesis
|
|
NMR struc:
|
|
20 models
|
|
|
Authors:
|
|
H.Endo,T.Nagashima,M.Yoshida,F.Hayashi,S.Yokoyama,Riken Structural Genomics/proteomics Initiative (Rsgi)
|
|
Key ref:
|
|
H.Endo
et al.
Solution structure of the c2 domain from human pi3-Kinase p110 subunit alpha.
To be published,
.
|
|
|
Date:
|
|
|
28-Mar-07
|
Release date:
|
01-Apr-08
|
|
|
|
|
|
|
PROCHECK
|
|
|
|
|
|
Headers
|
|
|
|
References
|
|
|
|
|
|
|
|
P42336
(PK3CA_HUMAN) -
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform from Homo sapiens
|
|
|
|
Seq:
Struc:
|
|
|
|
1068 a.a.
158 a.a.*
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Key: |
 |
PfamA domain |
|
|
 |
Secondary structure |
|
 |
CATH domain |
|
|
*
PDB and UniProt seqs differ
at 6 residue positions (black
crosses)
|
|
|
|
|
|
|
|
|
|
|
|
|
Enzyme class 2:
|
|
E.C.2.7.1.137
- phosphatidylinositol 3-kinase.
|
|
|
|
|
|
|
Pathway:
|
|
1-Phosphatidyl-myo-inositol Metabolism
|
|
|
|
|
|
Reaction:
|
|
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl- sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H+
|
|
|
|
|
|
1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)
|
+
|
ATP
|
=
|
1,2-diacyl- sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)
|
+
|
ADP
|
+
|
H(+)
|
|
|
|
|
|
|
|
|
|
Enzyme class 3:
|
|
E.C.2.7.1.153
- phosphatidylinositol-4,5-bisphosphate 3-kinase.
|
|
|
|
|
|
|
Pathway:
|
|
|
|
|
|
|
|
Reaction:
|
|
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5- trisphosphate) + ADP + H+
|
|
|
|
|
|
1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)
|
+
|
ATP
|
=
|
1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5- trisphosphate)
|
+
|
ADP
|
+
|
H(+)
|
|
|
|
|
|
|
|
|
|
Enzyme class 4:
|
|
E.C.2.7.11.1
- non-specific serine/threonine protein kinase.
|
|
|
|
|
|
|
Reaction:
|
|
|
1.
|
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
|
|
2.
|
L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H+
|
|
|
|
|
|
|
L-seryl-[protein]
|
+
|
ATP
|
=
|
O-phospho-L-seryl-[protein]
|
+
|
ADP
|
+
|
H(+)
|
|
|
|
|
|
|
L-threonyl-[protein]
|
+
|
ATP
|
=
|
O-phospho-L-threonyl-[protein]
|
+
|
ADP
|
+
|
H(+)
|
|
|
|
|
|
|
|
|
|
|
|
|
Note, where more than one E.C. class is given (as above), each may
correspond to a different protein domain or, in the case of polyprotein
precursors, to a different mature protein.
|
|
|
|
Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
|
|
|
|
Links
