PDBsum entry 2eli

Transferase

PDB id: 2eli

Contents

Protein chain

85 a.a. *

Metals

_ZN ×2

* Residue conservation analysis

PDB id:

2eli

Name:

Transferase

Title:

Solution structure of the second phorbol esters/diacylglycerol binding domain of human protein kinasE C alpha type

Structure:

Protein kinasE C alpha type. Chain: a. Fragment: c1_1. Synonym: pkc-alpha, pkc-a. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: prkca. Other_details: cell-free protein synthesis

NMR struc:

20 models

Authors:

N.Tochio,S.Koshiba,K.Saito,T.Tomizawa,S.Watanabe,T.Harada,T.Kigawa, S.Yokoyama,Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:

N.Tochio et al. Solution structure of the second phorbol esters/diacylglycerol binding domain of human protein kinase c alpha type. To be published, .

Date:

27-Mar-07 Release date: 01-Apr-08

Protein chain

P17252  (KPCA_HUMAN) -  Protein kinase C alpha type from Homo sapiens

Seq: 672 a.a.

Struc: 85 a.a.*

* PDB and UniProt seqs differ at 6 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.11.13 - protein kinase C.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site