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UniProt functional annotation for Q9UGK3 | ||
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| UniProt code: Q9UGK3. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Substrate of protein kinase PTK6. May play a regulatory role in the acute-phase response in systemic inflammation and may modulate STAT3 activity. {ECO:0000269|PubMed:10980601}. |
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| Subunit: | |
Interacts with PTK6 and CSF1R. {ECO:0000269|PubMed:10980601, ECO:0000269|PubMed:19393627}. |
| Subcellular location: | |
Cytoplasm {ECO:0000269|PubMed:10980601}. |
| Tissue specificity: | |
Widely expressed. {ECO:0000269|PubMed:10980601, ECO:0000269|PubMed:12540842}. |
| Ptm: | |
Phosphorylated on tyrosine. Tyr-250 may be important for interaction with kinases. Phosphorylated by PTK6 at Tyr-250 modulates PTK6-mediated STAT3 activation. Tyr-22 and Tyr-322 appears to be phosphorylated by SRC. {ECO:0000269|PubMed:12540842, ECO:0000269|PubMed:19393627}. |
| Miscellaneous: | |
[Isoform 2]: Alu insert from position 358 to 403. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.