PDBsum entry 2ekx

Signaling protein

PDB id: 2ekx

Contents

Protein chain

110 a.a. *

* Residue conservation analysis

PDB id:

2ekx

Name:

Signaling protein

Title:

Solution structure of the human bmx sh2 domain

Structure:

Cytoplasmic tyrosine-protein kinase bmx. Chain: a. Fragment: sh2 domain. Synonym: bone marrow tyrosine kinase gene in chromosome x protein, epithelial and endothelial tyrosine kinase, etk, ntk38. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: bmx. Other_details: cell-free protein synthesis

NMR struc:

20 models

Authors:

T.Kasai,S.Koshiba,S.Watanabe,T.Harada,T.Kigawa,S.Yokoyama,Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:

T.Kasai et al. Solution structure of the human bmx sh2 domain. To be published, .

Date:

26-Mar-07 Release date: 02-Oct-07

Protein chain

P51813  (BMX_HUMAN) -  Cytoplasmic tyrosine-protein kinase BMX from Homo sapiens

Seq: 675 a.a.

Struc: 110 a.a.*

* PDB and UniProt seqs differ at 6 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site