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UniProt functional annotation for Q8WV44 | ||
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| UniProt code: Q8WV44. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Functions as an E3 ligase that catalyzes the ubiquitin- mediated degradation of protein kinase C. {ECO:0000269|PubMed:17893151}. |
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| Catalytic activity: | |
Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; |
| Pathway: | |
Protein modification; protein ubiquitination. |
| Subunit: | |
Interacts with PRKCA (PubMed:17893151). Interacts with NOD2 (PubMed:27812135). {ECO:0000269|PubMed:17893151, ECO:0000269|PubMed:27812135}. |
| Subcellular location: | |
Cytoplasm {ECO:0000269|PubMed:16022281}. Nucleus {ECO:0000269|PubMed:16022281}. |
| Tissue specificity: | |
Expressed in multiple tissues with the highest levels in heart and skeletal muscle. {ECO:0000269|PubMed:17893151}. |
| Induction: | |
Down-regulated by muramyl-dipeptide and lipopolysaccharide. {ECO:0000269|PubMed:27812135}. |
| Ptm: | |
Auto-ubiquitinated. {ECO:0000269|PubMed:17893151}. |
| Similarity: | |
Belongs to the TRIM/RBCC family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.