UniProt functional annotation for Q9Y4P9



	UniProt functional annotation for Q9Y4P9

UniProt code: Q9Y4P9.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Microtubule-associated protein involved in the stabilization of microtubules along the axis of migration during radial intercalation. Promotes the establishment and stabilization of an axis of microtubules required for the active migration of cells into the outer epithelium (By similarity). Microtubule-associated protein that promotes microtubule bundling and stabilizes microtubules against depolymerization in response to cold shock (By similarity). Essential for ciliary central apparatus formation which requires both its microtubule-binding and bundling activities and for ciliary localization of HYDIN and SPAG6 in ependymal cilia (By similarity). Binds actin in intestinal epithelial cells (IECs), essential for IECs survival and contributes to formation of filopodia and lamellipodia in migrating IECs (PubMed:31473225). Regulates planar cell polarity signaling pathway and asymmetric microtubule accumulation in ciliated epithelia (By similarity). {ECO:0000250|UniProtKB:Q0IH24, ECO:0000250|UniProtKB:Q99JL1, ECO:0000269|PubMed:31473225}.

Subunit: Homodimer (By similarity). Interacts with actin, TJP1, CGN and CDH1 (PubMed:31473225). {ECO:0000250|UniProtKB:Q99JL1, ECO:0000269|PubMed:31473225}.

Subcellular location: Cytoplasm {ECO:0000269|PubMed:31473225}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q99JL1}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q0IH24}. Apical cell membrane {ECO:0000269|PubMed:31473225}. Basolateral cell membrane {ECO:0000269|PubMed:31473225}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:31473225}. Cell projection, microvillus {ECO:0000269|PubMed:31473225}. Cell projection, lamellipodium {ECO:0000269|PubMed:31473225}. Cell projection, filopodium {ECO:0000269|PubMed:31473225}. Note=Present in the tails of developing and epididymal sperm, internal to the fibrous sheath and around the outer dense fibers of the sperm flagellum. Also found at the apical tip of cilia (By similarity). Colocalizes with TJP1 and CGN at sites of cell-cell contact in intestinal epithelial cells (PubMed:31473225). {ECO:0000250|UniProtKB:Q0IH24, ECO:0000269|PubMed:31473225}.

Tissue specificity: Expressed in the intestinal epithelial cells (at protein level). {ECO:0000269|PubMed:31473225}.

Domain: The Calponin-homology domain mediates its binding to microtubules. {ECO:0000250|UniProtKB:Q99JL1}.

Miscellaneous: Radial intercalation is a developmentally reiterated form of migration by which cells move in a direction orthogonal to the plane of the tissue from an inner layer to an outer layer. {ECO:0000250|UniProtKB:Q0IH24}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Microtubule-associated protein involved in the stabilization of microtubules along the axis of migration during radial intercalation. Promotes the establishment and stabilization of an axis of microtubules required for the active migration of cells into the outer epithelium (By similarity). Microtubule-associated protein that promotes microtubule bundling and stabilizes microtubules against depolymerization in response to cold shock (By similarity). Essential for ciliary central apparatus formation which requires both its microtubule-binding and bundling activities and for ciliary localization of HYDIN and SPAG6 in ependymal cilia (By similarity). Binds actin in intestinal epithelial cells (IECs), essential for IECs survival and contributes to formation of filopodia and lamellipodia in migrating IECs (PubMed:31473225). Regulates planar cell polarity signaling pathway and asymmetric microtubule accumulation in ciliated epithelia (By similarity). {ECO:0000250\|UniProtKB:Q0IH24, ECO:0000250\|UniProtKB:Q99JL1, ECO:0000269\|PubMed:31473225}.


Subunit:		Homodimer (By similarity). Interacts with actin, TJP1, CGN and CDH1 (PubMed:31473225). {ECO:0000250\|UniProtKB:Q99JL1, ECO:0000269\|PubMed:31473225}.
Subcellular location:		Cytoplasm {ECO:0000269\|PubMed:31473225}. Cell projection, cilium, flagellum {ECO:0000250\|UniProtKB:Q99JL1}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250\|UniProtKB:Q0IH24}. Apical cell membrane {ECO:0000269\|PubMed:31473225}. Basolateral cell membrane {ECO:0000269\|PubMed:31473225}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000269\|PubMed:31473225}. Cell projection, microvillus {ECO:0000269\|PubMed:31473225}. Cell projection, lamellipodium {ECO:0000269\|PubMed:31473225}. Cell projection, filopodium {ECO:0000269\|PubMed:31473225}. Note=Present in the tails of developing and epididymal sperm, internal to the fibrous sheath and around the outer dense fibers of the sperm flagellum. Also found at the apical tip of cilia (By similarity). Colocalizes with TJP1 and CGN at sites of cell-cell contact in intestinal epithelial cells (PubMed:31473225). {ECO:0000250\|UniProtKB:Q0IH24, ECO:0000269\|PubMed:31473225}.
Tissue specificity:		Expressed in the intestinal epithelial cells (at protein level). {ECO:0000269\|PubMed:31473225}.
Domain:		The Calponin-homology domain mediates its binding to microtubules. {ECO:0000250\|UniProtKB:Q99JL1}.
Miscellaneous:		Radial intercalation is a developmentally reiterated form of migration by which cells move in a direction orthogonal to the plane of the tissue from an inner layer to an outer layer. {ECO:0000250\|UniProtKB:Q0IH24}.