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UniProt functional annotation for Q13017 | ||
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| UniProt code: Q13017. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
GTPase-activating protein for Rho family members (PubMed:8537347). {ECO:0000269|PubMed:8537347}. |
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| Subunit: | |
May interact with RASA1/p120GAP. {ECO:0000305|PubMed:8537347}. |
| Subcellular location: | |
Cytoplasm {ECO:0000269|PubMed:8537347}. Cell membrane {ECO:0000269|PubMed:8537347}; Peripheral membrane protein {ECO:0000269|PubMed:8537347}. Note=Also membrane-associated in a fibrillar pattern that colocalizes with the alpha5-beta1 integrin receptor (ITGA5/ITGB1) for fibronectin. {ECO:0000269|PubMed:8537347}. |
| Tissue specificity: | |
Detected in skin fibroblasts (at protein level) (PubMed:8537347). {ECO:0000269|PubMed:8537347}. |
| Domain: | |
The pG1 pseudoGTPase domain does not bind GTP. {ECO:0000269|PubMed:28894085}. |
| Sequence caution: | |
Sequence=AAA95963.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAH32723.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.