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UniProt functional annotation for Q9ULH1 | ||
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| UniProt code: Q9ULH1. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types (By similarity). Plays a role in ciliogenesis. {ECO:0000250, ECO:0000269|PubMed:20393563}. |
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| Activity regulation: | |
Activity stimulated by phosphatidylinositol 4,5- bisphosphate (PIP2). {ECO:0000250}. |
| Subunit: | |
Homodimer. Interacts with SRC and CRK. Interacts with RAB11FIP3. Interacts with PTK2B/PYK2 (By similarity). Interacts with CTTN. Interacts (via SH3 domain) with APC. Interacts with REPS2; the interaction is direct (PubMed:12149250). {ECO:0000250, ECO:0000269|PubMed:12149250, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:20509626}. |
| Subcellular location: | |
Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Note=Predominantly cytoplasmic. Partially membrane-associated. {ECO:0000250}. |
| Domain: | |
The PH domain most probably contributes to the phosphoinositide-dependent regulation of ADP ribosylation factors. {ECO:0000250}. |
| Ptm: | |
Phosphorylated on tyrosine residues by SRC. {ECO:0000250}. |
Annotations taken from UniProtKB at the EBI.