PDBsum entry 2ecy

Apoptosis

PDB id: 2ecy

Contents

Protein chain

66 a.a. *

Metals

_ZN ×2

* Residue conservation analysis

PDB id:

2ecy

Name:

Apoptosis

Title:

Solution structure of the zinc finger, c3hc4 type (ring finger)" domain of tnf receptor-associated factor 3

Structure:

Tnf receptor-associated factor 3. Chain: a. Fragment: ring-type, residues 8-66. Synonym: cd40 receptor-associated factor 1, craf1, cd40-binding protein, cd40bp, lmp1-associated protein, lap1, cap-1. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: traf3. Other_details: cell-free protein synthesis

NMR struc:

20 models

Authors:

H.Abe,K.Miyamoto,N.Tochio,M.Yoneyama,T.Kigawa,S.Yokoyama,Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:

H.Abe et al. Solution structure of the zinc finger, C3hc4 type (ring finger)" domain of tnf receptor-Associated factor 3. To be published, .

Date:

14-Feb-07 Release date: 26-Feb-08

Protein chain

Q13114  (TRAF3_HUMAN) -  TNF receptor-associated factor 3 from Homo sapiens

Seq: 568 a.a.

Struc: 66 a.a.*

* PDB and UniProt seqs differ at 7 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.3.2.27 - RING-type E3 ubiquitin transferase.
• Reaction: S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N₆- ubiquitinyl-[acceptor protein]-L-lysine