UniProt functional annotation for P15533



	UniProt functional annotation for P15533

UniProt code: P15533.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Trans-acting factor that regulates gene expression of interleukin 2 receptor alpha chain. May affect IL2R-alpha expression through cis-acting negative regulatory elements or through competition with proteins that bind to enhancer or activator sequences. Negatively regulates Toll-like receptor (TLR)-mediated activation of NFKB by promoting degradation of TAB2 and TAB3 and preventing TRAF6 autoubiquitination. Negatively regulates production of reactive oxygen species (ROS) which inhibits activation of the NLRP3 inflammasome complex. This, in turn, regulates activation of CASP1 and subsequent cleavage of IL1B and IL18. No activity detected against a range of retroviruses including a number of lentiviruses, gammaretroviruses and betaretroviruses. {ECO:0000269|PubMed:18345001, ECO:0000269|PubMed:19147168, ECO:0000269|PubMed:21048113}.

Subunit: Homomultimer. Interacts with NR2C2/TAK1, TAB2 and TAB3. Does not interact with NLRP3, NLRC4 or TAB1. {ECO:0000269|PubMed:18345001, ECO:0000269|PubMed:21048113}.

Subcellular location: Cytoplasm. Nucleus.

Tissue specificity: Highly expressed in spleen and lymph nodes (at protein level). {ECO:0000269|PubMed:18345001}.

Induction: By the TLR ligands lipopolysaccharide, CpG dinucleotide and polyinosinic-polycytidylic acid. {ECO:0000269|PubMed:18345001}.

Sequence caution: Sequence=AAA40073.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAG53470.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Trans-acting factor that regulates gene expression of interleukin 2 receptor alpha chain. May affect IL2R-alpha expression through cis-acting negative regulatory elements or through competition with proteins that bind to enhancer or activator sequences. Negatively regulates Toll-like receptor (TLR)-mediated activation of NFKB by promoting degradation of TAB2 and TAB3 and preventing TRAF6 autoubiquitination. Negatively regulates production of reactive oxygen species (ROS) which inhibits activation of the NLRP3 inflammasome complex. This, in turn, regulates activation of CASP1 and subsequent cleavage of IL1B and IL18. No activity detected against a range of retroviruses including a number of lentiviruses, gammaretroviruses and betaretroviruses. {ECO:0000269\|PubMed:18345001, ECO:0000269\|PubMed:19147168, ECO:0000269\|PubMed:21048113}.


Subunit:		Homomultimer. Interacts with NR2C2/TAK1, TAB2 and TAB3. Does not interact with NLRP3, NLRC4 or TAB1. {ECO:0000269\|PubMed:18345001, ECO:0000269\|PubMed:21048113}.
Subcellular location:		Cytoplasm. Nucleus.
Tissue specificity:		Highly expressed in spleen and lymph nodes (at protein level). {ECO:0000269\|PubMed:18345001}.
Induction:		By the TLR ligands lipopolysaccharide, CpG dinucleotide and polyinosinic-polycytidylic acid. {ECO:0000269\|PubMed:18345001}.
Sequence caution:		Sequence=AAA40073.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAG53470.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};