UniProt functional annotation for Q9UBF6



	UniProt functional annotation for Q9UBF6

UniProt code: Q9UBF6.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:10851089). CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (By similarity). Through the RING- type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents. {ECO:0000250|UniProtKB:P62877, ECO:0000269|PubMed:10851089}.

Pathway: Protein modification; protein ubiquitination.

Subunit: Probable part of SCF complexes, which consist of SKP1, CUL1, RNF7/RBX2 and a F-box protein. Interacts (preferentially) with CUL5. Also interacts (with lower preference) with CUL1, CUL2, CUL3, CUL4A and CUL4B. Interacts with UBE2F. Interacts with CSNK2B, the interaction is not affected by phosphorylation by CK2. May also interact with DCUN1D1, DCUN1D2, DCUN1D3, DCUN1D4 and DCUN1D5 (PubMed:26906416). {ECO:0000269|PubMed:10230407, ECO:0000269|PubMed:10851089, ECO:0000269|PubMed:19250909, ECO:0000269|PubMed:26906416}.

Subcellular location: Cytoplasm {ECO:0000269|PubMed:10082581}. Nucleus {ECO:0000269|PubMed:10082581}.

Tissue specificity: Expressed in heart, liver, skeletal muscle and pancreas. At very low levels expressed in brain, placenta and lung. {ECO:0000269|PubMed:10512750}.

Induction: By 1,10-phenanthroline. {ECO:0000269|PubMed:10082581}.

Domain: The RING-type zinc finger domain is essential for ubiquitin ligase activity. It coordinates an additional third zinc ion.

Ptm: Phosphorylation by CK2 is required for efficient degradation of NFKBIA and CDKN1B. {ECO:0000269|PubMed:12748192}.

Miscellaneous: [Isoform 2]: Inactive. {ECO:0000305}.

Similarity: Belongs to the RING-box family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:10851089). CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (By similarity). Through the RING- type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents. {ECO:0000250\|UniProtKB:P62877, ECO:0000269\|PubMed:10851089}.


Pathway:		Protein modification; protein ubiquitination.
Subunit:		Probable part of SCF complexes, which consist of SKP1, CUL1, RNF7/RBX2 and a F-box protein. Interacts (preferentially) with CUL5. Also interacts (with lower preference) with CUL1, CUL2, CUL3, CUL4A and CUL4B. Interacts with UBE2F. Interacts with CSNK2B, the interaction is not affected by phosphorylation by CK2. May also interact with DCUN1D1, DCUN1D2, DCUN1D3, DCUN1D4 and DCUN1D5 (PubMed:26906416). {ECO:0000269\|PubMed:10230407, ECO:0000269\|PubMed:10851089, ECO:0000269\|PubMed:19250909, ECO:0000269\|PubMed:26906416}.
Subcellular location:		Cytoplasm {ECO:0000269\|PubMed:10082581}. Nucleus {ECO:0000269\|PubMed:10082581}.
Tissue specificity:		Expressed in heart, liver, skeletal muscle and pancreas. At very low levels expressed in brain, placenta and lung. {ECO:0000269\|PubMed:10512750}.
Induction:		By 1,10-phenanthroline. {ECO:0000269\|PubMed:10082581}.
Domain:		The RING-type zinc finger domain is essential for ubiquitin ligase activity. It coordinates an additional third zinc ion.
Ptm:		Phosphorylation by CK2 is required for efficient degradation of NFKBIA and CDKN1B. {ECO:0000269\|PubMed:12748192}.
Miscellaneous:		[Isoform 2]: Inactive. {ECO:0000305}.
Similarity:		Belongs to the RING-box family. {ECO:0000305}.