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UniProt functional annotation for P10589 | ||
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| UniProt code: P10589. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG. {ECO:0000269|PubMed:10644740, ECO:0000269|PubMed:11682620}. |
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| Subunit: | |
Binds DNA as dimer; homodimer and probable heterodimer with NR2F6 (PubMed:11682620). Interacts with GTF2B; this interaction is direct (PubMed:1517211). Interacts with COPS2 (PubMed:10207062). {ECO:0000269|PubMed:10207062, ECO:0000269|PubMed:11682620, ECO:0000269|PubMed:1517211}. |
| Subcellular location: | |
Nucleus {ECO:0000305}. |
| Induction: | |
Inhibited by gonadotropin in granulosa cells. {ECO:0000269|PubMed:11682620}. |
| Disease: | |
Bosch-Boonstra-Schaaf optic atrophy syndrome (BBSOAS) [MIM:615722]: An autosomal dominant disorder characterized by optic atrophy associated with developmental delay and intellectual disability. Most patients also have evidence of cerebral visual impairment. {ECO:0000269|PubMed:24462372}. Note=The disease is caused by variants affecting the gene represented in this entry. |
| Similarity: | |
Belongs to the nuclear hormone receptor family. NR2 subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.