UniProt functional annotation for Q9UIF8



	UniProt functional annotation for Q9UIF8

UniProt code: Q9UIF8.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Chromatin reader protein, which may play a role in transcriptional regulation via interaction with ISWI (By similarity) (PubMed:10662543). Involved in positively modulating the rate of age- related behavioral deterioration (By similarity). Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with histone methyltransferase EHMT1 (By similarity). {ECO:0000250|UniProtKB:A2AUY4, ECO:0000303|PubMed:10662543}.

Subunit: Interacts with acetylated lysine residues on histone H1.4, H2A, H2B, H3 and H4 (in vitro). Interacts with EHMT1 (By similarity). {ECO:0000250|UniProtKB:A2AUY4, ECO:0000269|PubMed:22464331}.

Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00063}.

Tissue specificity: Expressed at varying levels in several tissues, whereas a smaller transcript was expressed specifically in testis.

Similarity: Belongs to the WAL family. {ECO:0000305}.

Sequence caution: Sequence=AAH12576.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAH12576.1; Type=Miscellaneous discrepancy; Note=contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA96000.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55231.1; Type=Erroneous initiation; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Chromatin reader protein, which may play a role in transcriptional regulation via interaction with ISWI (By similarity) (PubMed:10662543). Involved in positively modulating the rate of age- related behavioral deterioration (By similarity). Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with histone methyltransferase EHMT1 (By similarity). {ECO:0000250\|UniProtKB:A2AUY4, ECO:0000303\|PubMed:10662543}.


Subunit:		Interacts with acetylated lysine residues on histone H1.4, H2A, H2B, H3 and H4 (in vitro). Interacts with EHMT1 (By similarity). {ECO:0000250\|UniProtKB:A2AUY4, ECO:0000269\|PubMed:22464331}.
Subcellular location:		Nucleus {ECO:0000255\|PROSITE-ProRule:PRU00063}.
Tissue specificity:		Expressed at varying levels in several tissues, whereas a smaller transcript was expressed specifically in testis.
Similarity:		Belongs to the WAL family. {ECO:0000305}.
Sequence caution:		Sequence=AAH12576.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAH12576.1; Type=Miscellaneous discrepancy; Note=contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA96000.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55231.1; Type=Erroneous initiation; Evidence={ECO:0000305};