PDBsum entry 2e73

Transferase

PDB id: 2e73

Contents

Protein chain

77 a.a. *

Metals

_ZN ×2

* Residue conservation analysis

PDB id:

2e73

Name:

Transferase

Title:

Solution structure of the phorbol esters/diacylglycerol binding domain of protein kinasE C gamma

Structure:

Protein kinasE C gamma type. Chain: a. Fragment: c1 domain, residues 36-105. Synonym: pkc-gamma. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: prkcg, pkcg. Other_details: cell-free protein synthesis

NMR struc:

20 models

Authors:

W.Tanabe,S.Suzuki,Y.Muto,M.Inoue,T.Kigawa,T.Terada,M.Shirouzu, S.Yokoyama,Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:

W.Tanabe et al. Solution structure of the phorbol esters/diacylglycerol binding domain of protein kinase c gamma. To be published, .

Date:

05-Jan-07 Release date: 18-Dec-07

Protein chain

P05129  (KPCG_HUMAN) -  Protein kinase C gamma type from Homo sapiens

Seq: 697 a.a.

Struc: 77 a.a.*

* PDB and UniProt seqs differ at 7 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.11.13 - protein kinase C.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site