PDBsum entry 2e6s

Cell cycle

PDB id: 2e6s

Contents

Protein chain

77 a.a. *

Metals

_ZN ×3

* Residue conservation analysis

PDB id:

2e6s

Name:

Cell cycle

Title:

Solution structure of the phd domain in ring finger protein 107

Structure:

E3 ubiquitin-protein ligase uhrf2. Chain: a. Fragment: phd domain. Synonym: ubiquitin-like phd and ring finger domain-containing protein 2, ubiquitin-like-containing phd and ring finger domains protein 2, np95/icbp90-like ring finger protein, np95-like ring finger protein, nuclear zinc finger protein np97, ring finger protein 107. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: uhrf2, nirf, rnf107. Other_details: cell free protein synthesis

NMR struc:

20 models

Authors:

S.Kadirvel,F.He,Y.Muto,M.Inoue,T.Kigawa,M.Shirouzu,T.Terada, S.Yokoyama,Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:

S.Kadirvel et al. Solution structure of the phd domain in ring finger protein 107. To be published, .

Date:

28-Dec-06 Release date: 03-Jul-07

Protein chain

Q96PU4  (UHRF2_HUMAN) -  E3 ubiquitin-protein ligase UHRF2 from Homo sapiens

Seq: 802 a.a.

Struc: 77 a.a.*

* PDB and UniProt seqs differ at 8 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.3.2.27 - RING-type E3 ubiquitin transferase.
• Reaction: S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N₆- ubiquitinyl-[acceptor protein]-L-lysine