PDBsum entry 2dyn

Signal transduction

PDB id: 2dyn

Contents

Protein chains

111 a.a. *

Waters ×67

* Residue conservation analysis

References listed in PDB file

Key reference

• Title: Crystal structure of the pleckstrin homology domain from dynamin.
• Authors: D.Timm, K.Salim, I.Gout, L.Guruprasad, M.Waterfield, T.Blundell.
• Ref.: Nat Struct Biol, 1994, 1, 782-788.
• PubMed id: 7634088

Abstract

The pleckstrin homology (PH) domain is a conserved module present in many signal transducing and cytoskeletal proteins. Here we report the 2.8 A crystal structure of the PH domain from dynamin. This domain consists of seven beta-strands forming two roughly orthogonal antiparallel beta-sheets terminating with an amphipathic alpha-helix. The structure also reveals a non-covalent dimeric association of the PH domain and a hydrophobic pocket surrounded by a charged rim. The dynamin PH domain structure is discussed in relation to its potential role in mediating interactions between proteins.