PDBsum entry 2dyl

Transferase

PDB id: 2dyl

Contents

Protein chain

272 a.a. *

Waters ×37

* Residue conservation analysis

PDB id:

2dyl

Name:

Transferase

Title:

Crystal structure of human mitogen-activated protein kinase kinase 7 activated mutant (s287d, t291d)

Structure:

Dual specificity mitogen-activated protein kinase kinase 7. Chain: a. Fragment: kinase domain, residues 101-405. Synonym: mitogen-activated protein kinase kinase 7 gamma 1, map kinase kinase 7, mapkk 7, mapk/erk kinase 7, jnk-activating kinase 2, c-jun n-terminal kinase kinase 2, jnk kinase 2, jnkk 2. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Other_details: cell free protein synthesis

Resolution:

2.45Å R-factor: 0.217 R-free: 0.283

Authors:

M.Kukimoto-Niino,T.Takagi,T.Kaminishi,T.Uchikubo-Kamo,T.Terada, O.Matsuzaki,M.Shirouzu,S.Yokoyama,Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:

M.Kukimoto-Niino et al. Crystal structure of human mitogen-Activated protein kinase kinase 7 activated mutant (s287d, T291d). To be published, .

Date:

15-Sep-06 Release date: 28-Aug-07

Protein chain

O14733  (MP2K7_HUMAN) -  Dual specificity mitogen-activated protein kinase kinase 7 from Homo sapiens

Seq: 419 a.a.

Struc: 272 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.12.2 - mitogen-activated protein kinase kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺
  3. L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site