PDBsum entry 2dx0

Hydrolase

PDB id: 2dx0

Contents

Protein chains

117 a.a. *

95 a.a. *

Ligands

SO4 ×3

Waters ×102

* Residue conservation analysis

PDB id:

2dx0

Name:

Hydrolase

Title:

Crystal structure of the n-terminal sh2 domain of mouse phospholipase c-gamma 2

Structure:

PhospholipasE C, gamma 2. Chain: a, b. Fragment: n-terminal sh2 domain, residues 516-640. Engineered: yes

Source:

Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: cell-free protein synthesis.

Resolution:

2.50Å R-factor: 0.222 R-free: 0.262

Authors:

N.Handa,T.Takagi,K.Murayama,T.Terada,M.Shirouzu,S.Yokoyama,Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:

T.Takagi et al. Crystal structure of the n-Terminal sh2 domain of mouse phospholipase c-Gamma 2. To be published, .

Date:

22-Aug-06 Release date: 04-Sep-07

Protein chain

Q8CIH5  (PLCG2_MOUSE) -  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 from Mus musculus

Seq: 1265 a.a.

Struc: 117 a.a.

Protein chain

Q8CIH5  (PLCG2_MOUSE) -  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 from Mus musculus

Seq: 1265 a.a.

Struc: 95 a.a.

Enzyme reactions

• Enzyme class: Chains A, B: E.C.3.1.4.11 - phosphoinositide phospholipase C.
• Pathway: myo-Inositol Phosphate Metabolism
• Reaction: a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site