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PDBsum entry 2dwv
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Protein binding
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PDB id
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2dwv
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References listed in PDB file
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Key reference
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Title
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Solution structure of an atypical ww domain in a novel beta-Clam-Like dimeric form.
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Authors
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S.Ohnishi,
P.Güntert,
S.Koshiba,
T.Tomizawa,
R.Akasaka,
N.Tochio,
M.Sato,
M.Inoue,
T.Harada,
S.Watanabe,
A.Tanaka,
M.Shirouzu,
T.Kigawa,
S.Yokoyama.
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Ref.
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Febs Lett, 2007,
581,
462-468.
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PubMed id
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Abstract
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The WW domain is known as one of the smallest protein modules with a
triple-stranded beta-sheet fold. Here, we present the solution structure of the
second WW domain from the mouse salvador homolog 1 protein. This WW domain forms
a homodimer with a beta-clam-like motif, as evidenced by size exclusion
chromatography, analytical ultracentrifugation and NMR spectroscopy. While
typical WW domains are believed to function as monomeric modules that recognize
proline-rich sequences, by using conserved aromatic and hydrophobic residues
that are solvent-exposed on the surface of the beta-sheet, this WW domain buries
these residues in the dimer interface.
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