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UniProt functional annotation for P25440 | ||
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| UniProt code: P25440. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly. {ECO:0000250, ECO:0000269|PubMed:18406326}. |
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| Subunit: | |
Homodimer. Interacts with E2F1 and with histone H4 acetylated at 'Lys-13'. {ECO:0000269|PubMed:17148447, ECO:0000269|PubMed:18406326}. |
| Subunit: | |
(Microbial infection) Interacts with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:16227282}. |
| Subcellular location: | |
Nucleus {ECO:0000305}. Note=Detected on chromatin and nucleosomes. |
| Domain: | |
One bromodomain is sufficient for a partial interaction with histone H4 acetylated at 'Lys-13'. |
| Sequence caution: | |
Sequence=AAA68890.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.