UniProt functional annotation for P19706



	UniProt functional annotation for P19706

UniProt code: P19706.

Organism: Acanthamoeba castellanii (Amoeba).

Taxonomy: Eukaryota; Amoebozoa; Discosea; Longamoebia; Centramoebida; Acanthamoebidae; Acanthamoeba.

Function: Myosin is a protein that binds to F-actin and has ATPase activity that is activated by F-actin.

Subunit: Myosin I heavy chain is single-headed. Dimer of a heavy and a light chain. Inability to self-assemble into filaments.

Domain: Myosin tail domain binds directly to anionic phospholipid membranes; myosins I could therefore move actin relative to membranes and vice versa. TH.2 and SH3 bind tightly to F-actin; this together with the nucleotide-sensitive site in the head, allows single molecules of myosin I to cross-link actin filaments.

Miscellaneous: This organism expresses at least three isoforms of myosin I heavy-chain, encoded by genes MIA, MIB, and MIC.

Similarity: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Acanthamoeba castellanii (Amoeba).
Taxonomy:		Eukaryota; Amoebozoa; Discosea; Longamoebia; Centramoebida; Acanthamoebidae; Acanthamoeba.



Function:		Myosin is a protein that binds to F-actin and has ATPase activity that is activated by F-actin.


Subunit:		Myosin I heavy chain is single-headed. Dimer of a heavy and a light chain. Inability to self-assemble into filaments.
Domain:		Myosin tail domain binds directly to anionic phospholipid membranes; myosins I could therefore move actin relative to membranes and vice versa. TH.2 and SH3 bind tightly to F-actin; this together with the nucleotide-sensitive site in the head, allows single molecules of myosin I to cross-link actin filaments.
Miscellaneous:		This organism expresses at least three isoforms of myosin I heavy-chain, encoded by genes MIA, MIB, and MIC.
Similarity:		Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. {ECO:0000305}.